Gene expression profiling ofLeishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation
نویسندگان
چکیده
منابع مشابه
Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation.
Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. The limitations and possibilities associated with express...
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Using data from the Microarray Quality Control (MAQC) project, we demonstrate two data-analysis methods that shed light on the normalization of gene expression measurements and thereby on their technical variation. One is an improved method for normalization of multiple assays with mRNA concentrations related by a parametric model. The other is a method for characterizing limitations on the eff...
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ژورنال
عنوان ژورنال: Parasitology
سال: 2007
ISSN: 0031-1820,1469-8161
DOI: 10.1017/s0031182007003782